Erik Larsson

The paper identifies a novel BACH1 transcriptional signature in lung cancer cells, validated across multiple cell lines, and demonstrates its utility in detecting BACH1 perturbations and identifying inhibitors.

This study uses whole genome sequencing to trace the early origins of small intestine neuroendocrine tumors, showing that major genetic changes and metastases can originate in childhood or adolescence.

The paper uses post-mortem tissues to study mutational clonality in healthy tissues, finding smoking-induced clonal changes in oral epithelia and confirming NOTCH1/2-, TP53-, and FAT1-driven clones.

The paper identifies Kahuli as an Alk target in Drosophila visceral mesoderm using DamID profiling and shows its role in midgut constriction.

The paper analyzes genome sequences from multifocal SI-NET tumors to show they arise from independent clonal origins, lacking shared mutations.

The paper analyzes UV-induced mutational signatures, showing variability across chromatin states and improved modeling with extended sequence patterns.

The paper quantifies neoantigen depletion in cancer genomes and finds negligible depletion signals, suggesting weak or absent immunogenic negative selection.

This study identifies an extended context-specific mutational signature in melanoma promoter mutations, showing UV-induced vulnerability and subclonal mutation development in affected positions.