Author
Agency for Science, Technology and ResearchORCID 0000-0001-9009-0844Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Marcus K Preedy, Isobel Taylor-Hearn, Chen Ying…·Richard L. Mort
FluoroFate enables time-resolved single-cell analysis of cell fate by quantifying cell death dynamics using live-cell imaging and new biosensors.
Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang…·Motomi Osato
This paper demonstrates the use of eR1-CreERT2 transgenic mice to target and study hematopoietic stem cells (HSCs) across developmental stages, revealing stage-specific phenotypes and disease outcomes.
Ying Zhang, Kaijing Chen, Yichao Cai…·Melissa J. Fullwood
The paper identifies 'super-silencers' formed by chromatin interactions that regulate apoptotic genes and shows that combining GSK343 and X5050 disrupts these silencers to induce antitumor effects.
Fan Cao, Yu Zhang, Yichao Cai…·Melissa J. Fullwood
ChINN predicts chromatin interactions from DNA sequences, showing good performance across samples and identifying sequence features associated with interactions in CLL patient data.
Yichao Cai, Ying Zhang, Yan Ping Loh…·Melissa J. Fullwood
The paper identifies H3K27me3-rich regions as silencers that repress gene expression through chromatin interactions and shows their functional impact on cell identity and tumor growth.