Author
National University of SingaporeORCID 0000-0001-6484-9749Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Ying Zhang, Kaijing Chen, Seng Chuan Tang…·Melissa J. Fullwood
The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.
Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang…·Motomi Osato
This paper demonstrates the use of eR1-CreERT2 transgenic mice to target and study hematopoietic stem cells (HSCs) across developmental stages, revealing stage-specific phenotypes and disease outcomes.
Ying Zhang, Kaijing Chen, Yichao Cai…·Melissa J. Fullwood
The paper identifies 'super-silencers' formed by chromatin interactions that regulate apoptotic genes and shows that combining GSK343 and X5050 disrupts these silencers to induce antitumor effects.