Author
Agency for Science, Technology and ResearchORCID 0000-0001-5103-3054Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Ying Zhang, Kaijing Chen, Seng Chuan Tang…·Melissa J. Fullwood
The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.
Ying Zhang, Kaijing Chen, Yichao Cai…·Melissa J. Fullwood
The paper identifies 'super-silencers' formed by chromatin interactions that regulate apoptotic genes and shows that combining GSK343 and X5050 disrupts these silencers to induce antitumor effects.
Yichao Cai, Ying Zhang, Yan Ping Loh…·Melissa J. Fullwood
The paper identifies H3K27me3-rich regions as silencers that repress gene expression through chromatin interactions and shows their functional impact on cell identity and tumor growth.