Ying Zhang

This study investigates the mechanotransduction mechanism of ADGRG1/GPR56, revealing a dual-mode activation process that does not require NTF-CTF dissociation and depends on the Stachel element.

The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.

The paper identifies 'super-silencers' formed by chromatin interactions that regulate apoptotic genes and shows that combining GSK343 and X5050 disrupts these silencers to induce antitumor effects.

ChINN predicts chromatin interactions from DNA sequences, showing good performance across samples and identifying sequence features associated with interactions in CLL patient data.

The paper identifies H3K27me3-rich regions as silencers that repress gene expression through chromatin interactions and shows their functional impact on cell identity and tumor growth.