Author

Obinna C. Ubah

ORCID 0000-0001-9011-8405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aaron Matthew LeBeauiD· 1 shared Andrew J. PorteriD· 1 shared Caroline Jane BarelleiD· 1 shared David KosoffiD· 1 shared Eric W. Lake· 1 shared Gihan S. GunaratneiD· 1 shared Hideki AiharaiD· 1 shared Jayden L. WestiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aaron Matthew LeBeauORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyNature CommunicationsPeer-reviewedNov 29, 2025

The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors

Obinna C. Ubah, Eric W. Lake, Kendahl L. Ott…·Caroline Jane Barelle

This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.

8 citations

protein structureexperimental assay

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