Aaron Matthew LeBeau

This study identifies a shark-derived VNAR that binds a hidden epitope on FAP, revealing structural insights for multiepitope targeting strategies.

This study engineers single-domain antibodies to improve targeting of FAP, showing that valency and molecular weight affect tumor uptake and biodistribution.

This paper develops a shark-derived VNAR-based theranostic agent for MET-altered NSCLC, showing imaging and therapeutic efficacy in preclinical models.

This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.

The paper develops FAP-targeted theranostics using VNARs from a shark antibody library, showing high affinity and efficacy in vitro and in vivo.

This study shows that swapping nanobodies at specific AAV capsid hotspots enables precise tropism switching for targeted gene therapy without extensive optimization.