Author

David Kosoff

University of Wisconsin SystemORCID 0000-0001-8559-6357Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aaron Matthew LeBeauiD· 2 shared Gihan S. GunaratneiD· 2 shared Jayden L. WestiD· 2 shared Kendahl L. OttiD· 2 shared Andrew J. PorteriD· 1 shared Caroline Jane BarelleiD· 1 shared Eduardo Aluicio‐SarduyiD· 1 shared Eric W. Lake· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Aaron Matthew LeBeauORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyNature CommunicationsPeer-reviewedNov 29, 2025

The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors

Obinna C. Ubah, Eric W. Lake, Kendahl L. Ott…·Caroline Jane Barelle

This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.

8 citations

protein structureexperimental assay

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintJan 13, 2025

Development of FAP-targeted theranostics discovered by next-generation sequencing-augmented mining of a novel immunized VNAR library

Gihan S. Gunaratne, Joseph P. Gallant, Kendahl L. Ott…·Aaron Matthew LeBeau

The paper develops FAP-targeted theranostics using VNARs from a shark antibody library, showing high affinity and efficacy in vitro and in vivo.

2 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky