LTB4 is converted into a potent human neutrophil NADPH oxidase activator via a receptor transactivation mechanism in which the BLT1 receptor activates the free fatty acid receptor 2
Yan‐Ling Wu, Cláes Dahlgren, Huamei Fu Forsman, Martina Sundqvist
This study shows that an allosteric modulator of FFA2R converts LTB4 into a potent NADPH oxidase activator via BLT1R-FFA2R receptor transactivation.
Prostaglandins Leukotrienes and Essential Fatty Acids · Apr 5, 2025Peer-reviewedImmunology