Martina Sundqvist

The free fatty acid 2 receptor regulates the activation potency of C5a and the sensitivity to the antagonist avacopan

This study shows that the free fatty acid 2 receptor modulates C5a receptor signaling, enhancing NADPH oxidase activation and reducing the effect of the antagonist avacopan.

THE ACTIN CYTOSKELETON CONTROLS NADPH OXIDASE ACTIVATION AND G PROTEIN RECRUITMENT MEDIATED BY NEUTROPHIL G-alpha-q-COUPLED RECEPTORS

This paper shows that the actin cytoskeleton regulates NADPH oxidase activation and G protein recruitment in neutrophils via Gq-coupled receptors.

Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique

This study identifies HCA3R as a new GPCR in human neutrophils and shows it activates NADPH oxidase with specific pre-treatment requirements.

LTB4 is converted into a potent human neutrophil NADPH oxidase activator via a receptor transactivation mechanism in which the BLT1 receptor activates the free fatty acid receptor 2

This study shows that an allosteric modulator of FFA2R converts LTB4 into a potent NADPH oxidase activator via BLT1R-FFA2R receptor transactivation.

Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide receptors

This study shows that Larixol does not inhibit Gi or Gq containing G proteins in human neutrophils, contradicting previous claims about its inhibitory effects on FPR1 and related receptors.