Cláes Dahlgren

The paper shows that FFA2R modulates NADPH oxidase activity induced by FPR agonists, revealing distinct signaling pathways activated by FPRs.

This study investigates FFA2R allosterism across cell models, showing pathway-selective modulation and highlighting Ca2+ mobilization and ROS as therapeutic readouts.

This study shows that the free fatty acid 2 receptor modulates C5a receptor signaling, enhancing NADPH oxidase activation and reducing the effect of the antagonist avacopan.

This paper shows that the actin cytoskeleton regulates NADPH oxidase activation and G protein recruitment in neutrophils via Gq-coupled receptors.

This study identifies HCA3R as a new GPCR in human neutrophils and shows it activates NADPH oxidase with specific pre-treatment requirements.

This study shows that an allosteric modulator of FFA2R converts LTB4 into a potent NADPH oxidase activator via BLT1R-FFA2R receptor transactivation.

This study shows that Larixol does not inhibit Gi or Gq containing G proteins in human neutrophils, contradicting previous claims about its inhibitory effects on FPR1 and related receptors.