Marcus Saarinen

Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms

The paper identifies a constitutively active mutant of the dopamine D2 receptor using computational methods and experimental validation.

Revealing molecular determinants of ligand efficacy and affinity at the D2 dopamine receptor through molecular dynamics simulations

This study uses molecular dynamics simulations to uncover the molecular mechanisms of ligand activation in the D2 dopamine receptor and identifies differences in activation mechanisms between dopamine and adrenergic receptors.