Revealing molecular determinants of ligand efficacy and affinity at the D2 dopamine receptor through molecular dynamics simulations
Yue Chen, Nour Aldin Kahlous, Marcus Saarinen, Sergio Pérez-Conesa, Per Svenningsson, Lucie Delemotte, Jens Carlsson
This study uses molecular dynamics simulations to uncover the molecular mechanisms of ligand activation in the D2 dopamine receptor and identifies differences in activation mechanisms between dopamine and adrenergic receptors.
bioRxiv · Mar 30, 2025 · PreprintBiophysics