Mónica González-Magaldi

The paper uses cryo-electron tomography to study the structure of full-length EGFR in extracellular vesicles, revealing its clustering and signaling domain positioning.

The paper investigates the role of specific transmembrane dimers in EGFR activity and finds that many transmembrane sequences are compatible with EGFR function without requiring specific dimer conformations.

The paper shows that the extracellular regions of RTKs regulate downstream signaling, with EGFR extracellular regions activating multiple RTK classes, while Fc-RTK chimeras fail to activate effectors.