Ophelia Papoulas

La1: an evolutionarily conserved player in the Arabidopsis telomerase complex

This paper identifies AtLa1 as an essential RNA-binding factor for Arabidopsis telomerase function, revealing its role in telomerase complex assembly and highlighting evolutionary conservation with yeast and ciliate proteins.

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases

The paper reconstructs the protein interactome of the Last Eukaryotic Common Ancestor and identifies new human gene-disease associations for bone density and congenital birth defects.

Comparative Proteomic Profiling of Receptor Kinase Signaling Reveals Key Trafficking Components Enforcing Plant Stomatal Development

The paper identifies key trafficking components involved in ERECTA receptor kinase signaling that regulate plant stomatal development through endocytosis.

A protein complex in the extreme distal tip of vertebrate motilecilia controls their organization, length, and function

The paper identifies two proteins, Ccdc78 and Ccdc33, at the distal tip of vertebrate motile cilia, showing they are essential for cilia organization, length regulation, and function.

The CAGE complex: a hollow, megadalton, protein assembly in prokaryotic and eukaryotic microbes

The paper identifies and characterizes a new conserved protein complex, CAGE, found in both prokaryotes and eukaryotes, revealing its structural features and evolutionary distribution.

Physical and functional interaction of Lrrc56 and Odad3 controls deployment of axonemal dyneins in vertebrate multiciliated cells

The paper investigates the role of Lrrc56 in vertebrate multiciliated cells, showing it regulates outer dynein arm deployment through interaction with Odad3, linking LRRC56 mutations to primary ciliary dyskinesia.

Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography

The paper uses cryo-electron tomography to study the structure of full-length EGFR in extracellular vesicles, revealing its clustering and signaling domain positioning.

VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution

VerteBrain maps conserved brain protein interactions across five vertebrate species, revealing novel complexes and disease mechanisms.

Does AlphaFold2 model proteins' intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins

The paper tests if AlphaFold2 accurately models intracellular protein conformations using cross-linking mass spectrometry of endogenous ciliary proteins in Tetrahymena thermophila.

Protein nonadditive expression and solubility in Arabidopsis hybrids and allotetraploids

The paper analyzes proteomic changes in Arabidopsis hybrids and allotetraploids, finding nonadditive protein expression and increased solubility of photosynthetic proteins associated with hybrid vigor.

The protein organization of a red blood cell

This study defines the RBC proteome and interactome using mass spectrometry and machine learning, revealing key biological processes and structural models.

Cell adhesions link subcellular actomyosin dynamics to tissue scale force production during vertebrate convergent extension.

The paper investigates how Arvcf catenin links subcellular actomyosin dynamics to tissue-scale force production during vertebrate convergent extension.

A systematic, label-free method for identifying RNA-associated proteins in vivo provides insights into vertebrate ciliary beating

The paper introduces DIF-FRAC, a label-free method to identify RNA-associated proteins in vertebrate tissues, revealing novel RAPs and RNA-enriched organelles.

Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveals coordinate control of lipid metabolism

The paper presents experiment-matched datasets of RNAs, proteins, metabolites, and lipids in budding yeast during the cell cycle, revealing coordinated control of lipid metabolism.

A pan-plant protein complex map reveals deep conservation and novel assemblies

The paper maps protein complexes across 13 plant species, revealing conserved and novel assemblies with agricultural relevance.