Author

Chaseley E. McKenzie

The University of MelbourneORCID 0000-0001-9022-5702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Christopher A. ReidiD· 3 shared Ming S. SohiD· 3 shared A. Marie PhillipsiD· 2 shared Christopher SemsarianiD· 2 shared Erlina S. Mohamed Syazwan· 2 shared Ingrid Eileen SchefferiD· 2 shared Lauren E. BleakleyiD· 2 shared Samuel Frank BerkoviciD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Christopher A. ReidORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 9, 2024

A precision medicine approach for HCN1 Developmental and Epileptic Encephalopathy

Lauren E. Bleakley, Chaseley E. McKenzie, Da You Zhao…·Christopher A. Reid

This study evaluates the therapeutic potential of Org 34167, an HCN channel inhibitor, for HCN1-DEE using multiple assays, showing efficacy in reducing cation leak and seizures but with side effects.

DOI 10.1101/2024.01.09.574555

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 10, 2023

Atenolol reduces cardiac-mediated mortality in a genetic mouse model of sudden unexpected death in epilepsy

Ming S. Soh, Alibek Kuanyshbek, Erlina S. Mohamed Syazwan…·Christopher A. Reid

This study shows that atenolol reduces cardiac-related mortality in a genetic mouse model of SUDEP by mitigating seizure and LQTS interactions.

DOI 10.1101/2023.12.10.570964

mousestatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 19, 2021

Loss-of-function variants in the cardiac Kv11.1 channel as a genetic biomarker for SUDEP

Ming S. Soh, Richard D. Bagnall, Mark F. Bennett…·Christopher A. Reid

The paper identifies loss-of-function KCNH2 variants as enriched in SUDEP patients compared to epilepsy controls, suggesting a genetic biomarker for SUDEP risk.

1 citation

humanwhole-exome sequencing

𝕏 PostBluesky