Author

Ming S. Soh

The University of MelbourneORCID 0000-0002-5689-2082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Chaseley E. McKenzieiD· 3 shared Christopher A. ReidiD· 3 shared A. Marie PhillipsiD· 2 shared Christopher SemsarianiD· 2 shared Erlina S. Mohamed Syazwan· 2 shared Ingrid Eileen SchefferiD· 2 shared Lauren E. BleakleyiD· 2 shared Samuel Frank BerkoviciD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Chaseley E. McKenzieORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A precision medicine approach for HCN1 Developmental and Epileptic Encephalopathy

Lauren E. Bleakley, Chaseley E. McKenzie, Da You Zhao, Ming S. Soh, James Spyrou, Ian Cameron Forster, Bang Viet Bui, Christopher A. Reid

This study evaluates the therapeutic potential of Org 34167, an HCN channel inhibitor, for HCN1-DEE using multiple assays, showing efficacy in reducing cation leak and seizures but with side effects.

bioRxiv · Jan 9, 2024 · PreprintNeuroscience

Atenolol reduces cardiac-mediated mortality in a genetic mouse model of sudden unexpected death in epilepsy

Ming S. Soh, Alibek Kuanyshbek, Erlina S. Mohamed Syazwan, Hian M. Lee, Chaseley E. McKenzie, A. Marie Phillips, Amanda Hu, Ingrid Eileen Scheffer, Christopher Semsarian, Samuel Frank Berkovic, Christopher A. Reid

This study shows that atenolol reduces cardiac-related mortality in a genetic mouse model of SUDEP by mitigating seizure and LQTS interactions.

bioRxiv · Dec 10, 2023 · PreprintNeuroscience

Loss-of-function variants in the cardiac Kv11.1 channel as a genetic biomarker for SUDEP

Ming S. Soh, Richard D. Bagnall, Mark F. Bennett, Lauren E. Bleakley, Erlina S. Mohamed Syazwan, A. Marie Phillips, Mathew D. F. Chiam, Chaseley E. McKenzie, Michael S. Hildebrand, Douglas Ewan Crompton, Melanie Bahlo, Christopher Semsarian, Ingrid Eileen Scheffer, Samuel Frank Berkovic, Christopher A. Reid

The paper identifies loss-of-function KCNH2 variants as enriched in SUDEP patients compared to epilepsy controls, suggesting a genetic biomarker for SUDEP risk.

bioRxiv · Mar 19, 2021 · PreprintNeuroscience

Disruption of genes associated with Charcot-Marie-Tooth type 2 lead to common behavioural, cellular and molecular defects in Caenorhabditis elegans

Ming S. Soh, Xinran Cheng, Jie Liu, Brent Neumann

This study shows that disrupting CMT2-associated genes in C. elegans causes similar movement, muscle, and neuromuscular junction defects.

bioRxiv · Apr 11, 2019 · PreprintNeuroscience