NeurosciencebioRxivPreprint
Injectable borax-loaded alginate hydrogels reduce muscle atrophy, modulate inflammation, and generate neuroprotection in the SOD1G93A mouse model of ALS via activation of the IGF-Akt-mTOR axis pathway.
Ana Rodríguez-Romano, Juan Gonzalez-Valdivieso, Laura Moreno‐Martínez…·Patricia Rico
The paper demonstrates that injectable borax-loaded alginate hydrogels improve motor function and survival in SOD1G93A mice by activating the IGF-Akt-mTOR pathway in muscle, reducing atrophy and inflammation.
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