Rosario Osta

This study shows that loss of TDP-43 causes premature aging in skeletal muscle stem cells, reducing their regenerative capacity and leading to muscle degeneration.

The paper identifies early ALS-related lipid changes in presymptomatic SOD1G93A mice using lipid imaging mass spectrometry, showing sex-dependent and fiber-type-specific alterations detectable before symptoms.

This study investigates the effects of systemic FOXO1 inhibition in hSOD1G93A mice, finding limited therapeutic benefit in modifying disease progression or muscle pathology.

The paper identifies kranocytes as sensory platforms in neuromuscular junctions that connect adjacent junctions, interact with microvasculature, and respond to injury or disease.

This study tests a novel FKBP12 ligand, MP-010, in ALS mice, showing improved motor function, preserved motor neurons, and extended lifespan.

The paper demonstrates that injectable borax-loaded alginate hydrogels improve motor function and survival in SOD1G93A mice by activating the IGF-Akt-mTOR pathway in muscle, reducing atrophy and inflammation.