Lok‐To Sham

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

This paper identifies the WalRK two-component system's role in maintaining cell envelope integrity by compensating for reduced capsule and wall teichoic acid attachment in Streptococcus pneumoniae.

The paper identifies how VncS cross-phosphorylates RR06 to activate CbpA, a key adhesin in Streptococcus pneumoniae, resolving a mechanistic controversy.

This study shows plasma ficolins enable liver macrophages to capture blood-borne bacteria by recognizing capsular polysaccharides, enhancing immune response against encapsulated bacteria.

The paper introduces Dual Tn-seq to assess genome-wide genetic interactions in Streptococcus pneumoniae by analyzing double mutants, revealing new biochemical pathway components.