David I. Roper

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

This paper develops a high-throughput fluorescence anisotropy assay to measure peptidoglycan-digesting enzyme activity, enabling rapid and specific analysis of enzyme-substrate interactions.

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

This study identifies the enzymatic function of PcsB, a peptidoglycan hydrolase in Streptococcus pneumoniae, showing it cleaves Lys-containing, amidated peptidoglycan and is regulated by structural changes.

This study identifies the molecular function and delivery determinants of the T6SS effector Tae17 in Acinetobacter baumannii, showing it is a bifunctional peptidoglycan hydrolase with lytic transglycosylase and amidase activities.

This study identifies GarP as a regulator of PBP1a activity in S. pneumoniae, revealing its role in coordinating cell wall remodeling during cell division.