Jose Maria Moraleda

This study shows that direct reprogramming of human somatic cells into neurons involves a transient intermediate state, with cells exhibiting neuronal markers and functional properties.

This study shows human bone marrow-derived mesenchymal cells can transdifferentiate into neural-like cells without cell fusion, forming binucleated cells through nuclear movement.

This study shows that human adult stem cells differentiate into neural cells through a de-differentiation step followed by re-differentiation, confirmed by observing morphology changes and micronuclei movement.