Salvador Martı́nez

A Genetic Atlas of Direct and Inverse Neuropsychiatric-Cancer Comorbidity

The paper identifies genetic correlations between neuropsychiatric disorders and cancers, revealing shared and opposing biological mechanisms.

Direct reprogramming of human somatic cells into neuron-like cells involves a transition through a transient intermediate state.

This study shows that direct reprogramming of human somatic cells into neurons involves a transient intermediate state, with cells exhibiting neuronal markers and functional properties.

Challenges and promises in optimising a non-clinical protocol of intracerebroventricular human neural stem cell transplantation in ALS

This study evaluates the safety and efficacy of human neural stem cell transplantation in ALS using immunodeficient mice, finding it safe and showing potential therapeutic benefits with prolonged immunosuppression.

MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS

This study identifies MOK as a kinase regulating microglial inflammatory responses and type-I IFN through Brd4, showing its involvement in ALS pathogenesis.

Binucleated cells generated by nuclear movement during neural transdifferentiation from human bone marrow-derived mesenchymal cells

This study shows human bone marrow-derived mesenchymal cells can transdifferentiate into neural-like cells without cell fusion, forming binucleated cells through nuclear movement.

Differentiation of human adult-derived stem cells towards a neural lineage involves a de-differentiation event prior to re-differentiation to neural phenotypes

This study shows that human adult stem cells differentiate into neural cells through a de-differentiation step followed by re-differentiation, confirmed by observing morphology changes and micronuclei movement.

Non-proliferative adult neurogenesis in neural crest-derived stem cells isolated from human periodontal ligament.

This study investigates the morphological changes during neurogenesis in human periodontal ligament stem cells, revealing transient nuclear lobulation not linked to proliferation and similar to in vivo neurogenic niches.