Thomas Deffieux

This paper introduces a sparse deconvolution framework to enhance resolution in ultrafast power Doppler ultrasound imaging, improving microvascular and functional brain imaging without contrast agents.

SVD-SN2N improves denoising of SVD-filtered ultrasound images by converting multiplicative speckle to additive noise, enhancing SNR and vessel resolution without requiring clean references or raw data.

This paper introduces MS-SVD, a multi-stage SVD framework for ultrafast CEUS imaging that improves microbubble detection and vascular contrast by separating nonlinear signals from tissue clutter.

This study uses 3D ULM with Row-Column Arrays to image and quantify microvascular flow in mouse brains, differentiating arterial and venous subgraphs and extracting vascular metrics across 66 classes.

The paper examines brain network plasticity during neuropathic pain onset and maintenance in mice, finding stable connectivity during maintenance and changes at onset and post-surgery.

This paper evaluates and benchmarks motion artifact removal strategies in functional ultrasound imaging of awake mice, identifying optimal methods to improve data reliability.

This paper develops a non-invasive transcranial ultrasound imaging method in non-human primates, achieving high-resolution vascular visualization and flow quantification.

This paper introduces HAM-SVD, a method for ultrafast ultrasound imaging of gas vesicles that improves signal-to-background ratio compared to existing techniques.

This paper introduces nonlinear singular value decomposition beamforming for ultrasound imaging of gas vesicles, achieving comparable sensitivity to existing methods with fewer pulse transmissions and improved signal-to-background ratio.

The paper shows that activity in the SEF and MCC predicts voluntary task resumption in macaques, revealing their opposing roles in initiating and pausing actions.

PhysiofUS uses ultrafast ultrasound to automatically detect heart and breathing rates from tissue motion in rodents and human neonates, validated against gold-standard electrodes.

This study introduces a novel transcranial whole-brain fUS and ULM technique in mice using multilinear probes, revealing vessel-level dependencies in neurovascular responses.

This study examines opioid-induced changes in brain activation and functional connectivity in awake mice, finding that dysconnectivity correlates with analgesia.

This paper develops a non-invasive biomarker using functional ultrasound imaging to quantify myelin loss in a mouse model of multiple sclerosis.

This study uses functional ultrasound imaging in awake mice to reveal brain state dynamics during cold perception, identifying new patterns of interregional connectivity and affective responses.

This study demonstrates a closed-loop ultrasonic brain-machine interface that enables nonhuman primates to control movements using real-time neurovascular activity predictions.

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

This study shows that single neuron activity and cerebral blood volume changes are uncorrelated during rest but correlated during tasks in non-human primates.

This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.

The paper investigates the relationship between pupil dilation and SEF activity during cognitive tasks in macaques, finding that SEF neurovascular activity predicts pupil diameter changes.

The paper examines neurovascular interactions in running rats, finding that brain hemodynamics change across trials despite constant running speed and theta activity.

This study uses functional ultrasound imaging to map retinotopic and ocular dominance columns in the visual cortex of awake non-human primates with high spatiotemporal resolution.