Serge A. Picaud

Increased sensitivity to myopia and altered retinal ON/OFF balance in a mouse model lacking Dusp4

This study investigates the role of Dusp4 in myopia development using a mouse model, finding altered retinal ON/OFF balance and increased sensitivity to myopia.

From Functional Organization to Vascular Structure in the Primate Visual Cortex Using Ultrasound Imaging

This study uses functional ultrasound imaging and ultrasound localization microscopy to examine retinotopic maps and vascular structure in the primate visual cortex.

Endothelial NMDA receptor involvement in retinal neurovascular damage following prenatal alcohol exposure in mouse model

This study shows that endothelial NMDA receptors are critical for retinal vascular development and mediate prenatal alcohol exposure-induced neurovascular defects in mice.

A flexible high-precision photoacoustic retinal prosthesis

This paper presents a photoacoustic retinal prosthesis that stimulates retinal cells with high precision and safety, showing neural modulation in rat models.

WFS1E864K in humans and mice causes Wolfram-like syndrome optic atrophy via early axonal mitochondrial dysfunction

Ectopic expression of two cone opsins in mouse RGCs results in opposite responses to light stimulation, likely due to differential G protein activation

This study shows that expressing short-wavelength cone opsin in RGCs causes hyperpolarization, opposite to mid-wavelength opsin's depolarization, due to different G-protein activation.

Optogenetic stimulation recruits cortical neurons in amorphology-dependent manner

This study shows that optogenetic stimulation activates cortical neurons in a morphology-dependent manner, with lateral spread influenced by neuronal layer and stimulation intensity.

Covariations of cerebral blood volume and single neurons discharge during resting state and behavioral visual cognitive tasks in non-human primates

This study shows that single neuron activity and cerebral blood volume changes are uncorrelated during rest but correlated during tasks in non-human primates.

Failed remyelination of the non-human primate optic nerve leads to axon degeneration, retinal damages and visual dysfunction.

This paper presents a non-human primate model of optic nerve demyelination that recapitulates key features of MS lesions, showing failed remyelination, axonal degeneration, and visual dysfunction.

In vivo optogenetic stimulation of the primate retina activates the visual cortex after long-term transduction

This study shows that optogenetic stimulation of the primate retina can activate the visual cortex for over 20 months, demonstrating long-term functionality and signal transmission.

Sonogenetic stimulation of the brain at a spatiotemporal resolution suitable for vision restoration

This paper demonstrates sonogenetic stimulation of the brain with high spatiotemporal resolution for visual restoration in rats and rodents.

Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex

This study uses optogenetics and functional ultrasound imaging to show that surface stimulation of the rat visual cortex activates a large volume of V1, including deep layers and areas beyond V1.

Optogenetic therapy: High spatiotemporal resolution and pattern recognition compatible with vision restoration in non-human primates

The paper evaluates an optogenetic construct for vision restoration in non-human primates, demonstrating high temporal resolution and visual acuity above legal blindness.

Functional ultrasound imaging of deep visual cortex in awake non-human primates

This study uses functional ultrasound imaging to map retinotopic and ocular dominance columns in the visual cortex of awake non-human primates with high spatiotemporal resolution.

All-optical interrogation of a direction selective retinal circuit by holographic wave front shaping

The paper demonstrates that rod bipolar cells provide asymmetric input to direction selective ganglion cells, contributing to their direction selectivity through all-optical manipulation and imaging.

Optogenetic vision restoration with high resolution

This study demonstrates that optogenetically activated ganglion cells in mouse and macaque retinas have high spatial resolution, predicting acuity above legal blindness limits.

Modeling the Electro-chemical Properties of Microbial Opsin ChrimsonR for Application to Optogenetics-based Vision Restoration

The paper develops a model to predict ChrimsonR's electrochemical behavior under light stimulation, capturing its dynamics and adaptation mechanisms for optogenetics applications.

Multiplexed computations in retinal ganglion cells of a single type

The paper shows that a single type of retinal ganglion cell encodes two different visual features depending on stimulus context.