Chaim Glück

Brain pericytes exhibit spatially organized and dynamically regulated molecular heterogeneity

This study identifies spatial and dynamic molecular heterogeneity in adult mouse brain pericytes across anatomical regions, vascular positions, aging, ischemia, and circadian phases.

Opportunistic neuronal fuelling

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

ECgo: All-Optical Induction of Single Endothelial Cell Injury and Capillary Occlusion in the Brain

The paper introduces ECgo, an optical method to induce single endothelial cell injury and capillary occlusion in the mouse brain with high spatial precision, enabling studies of capillary repair and dysfunction.

Streak-Aware Localization Microscopy Enables High-Throughput Brain Imaging Across Platforms

SALM uses deep learning to convert motion-blurred streaks into high-resolution brain imaging, reducing reconstruction time and enabling scalable, cross-platform applications.

Reprogrammed neutrophils with impaired transit mechanics drive multi-organ capillary stalling after stroke

This study identifies reprogrammed neutrophils with impaired transit mechanics as a driver of multi-organ capillary stalling after stroke, showing therapeutic potential through Fgr inhibition.

Pial collaterals propagate neurovascular responses across functional units

The paper shows pial collaterals propagate neurovascular signals between cortical territories, synchronizing blood flow responses beyond activated areas.

Transcranial cortex-wide imaging of murine ischemic perfusion with large-field multifocal illumination fluorescence microscopy

This paper develops a new imaging technique to study brain perfusion in mice during ischemic stroke, showing its ability to map vascular changes and assess therapeutic effects.

Bessel Beam Optical Coherence Microscopy Enables Multiscale Assessment of Cerebrovascular Network Morphology and Function

This study introduces Bessel beam optical coherence microscopy to assess cerebrovascular network morphology and function in mice at high resolution and across multiple scales.

Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion

Pia-FLOW maps hemodynamic properties of the murine pial vascular network and shows its unified response to arterial occlusion.

L-Type calcium channels and TRPC3 channels shape brain pericyte calcium signaling and hemodynamics throughout the arteriole to capillary network in vivo

This study investigates the role of L-type and TRPC3 calcium channels in pericyte calcium signaling and hemodynamics across different cerebrovascular regions in vivo.

Leptomeningeal collaterals regulate reperfusion in ischemic stroke

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

Distinct signatures of calcium activity in brain pericytes

This study identifies distinct calcium activity patterns in brain pericyte subtypes, showing differences in dynamics and responses to neuronal activity and extracellular potassium.