Cancer BiologyCancer ResearchPeer-reviewed
Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma
Jung Hyun Um, Yueyuan Zheng, Qiong Mao…·De‐Chen Lin
This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.
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