Author

Takako Takeda

Harvard UniversityORCID 0000-0001-9140-1018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

A. Dinis· 1 shared Anish VasaniD· 1 shared Donald E. IngberiD· 1 shared E. Gardner· 1 shared Frédéric VigneaultiD· 1 shared Jerrold R. TurneriD· 1 shared K. Shcherbina· 1 shared Megan M. SperryiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

A. Dinis

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Target-agnostic discovery of Rett Syndrome therapeutics by coupling computational network analysis and CRISPR-enabled in vivo disease modeling

R. Novak, Tiffany Lin, S. Kaushal, Megan M. Sperry, Frédéric Vigneault, E. Gardner, Sahil Loomba, K. Shcherbina, Vishal Keshari, A. Dinis, Anish Vasan, V. Chandrasekhar, Takako Takeda, Jerrold R. Turner, Michael G. Levin, Donald E. Ingber

This paper identifies vorinostat as a potential repurposed therapy for Rett syndrome by combining computational network analysis with CRISPR-edited Xenopus models, showing efficacy across multiple organ systems.

bioRxiv · Mar 20, 2022 · PreprintNeuroscience