Donald E. Ingber

This study shows that a probiotic reduces radiation-induced intestinal damage by lowering oxidative stress in a human gut-on-a-chip model.

The paper shows brain shuttle target expression varies between individuals but not by brain region, disease, age, or sex.

This study shows that lung-targeted delivery of immunostimulatory dsRNA via LNPs enhances systemic cytokine responses and antitumor activity in melanoma models.

The paper develops a human fallopian tube-on-a-chip model to test non-hormonal contraceptives, showing dose-dependent sperm motility inhibition by TDI-11861.

Endolysin BNT331 combined with Lactobacillus crispatus reduces bacterial load and suppresses inflammation in a human vagina chip model of bacterial vaginosis.

This study identifies CLK2 as a therapeutic target for acute radiation syndrome by showing CLK2 inhibitors protect endothelial cells and reverse radiation injury in human organ models.

The paper shows cytokines control the physical state of immune tissue by modulating the fluidity of B cell structures, revealing a new biophysical mechanism of immune regulation.

Molecular dynamic simulations reveal flavonoids self-assemble into ordered structures that interact with proteins, modulate enzyme activity, and protect cells from UV-induced injury.

This paper develops shear-activated nanoparticles delivering nitroglycerin to improve ischaemic stroke outcomes by enhancing collateral vessel perfusion.

The paper identifies broad-spectrum coronavirus inhibitors using molecular dynamics and AI docking, showing efficacy against SARS-CoV-2 and related viruses in cell and mouse models.

The paper uses human endocervix chips to show that IL-1 receptor antagonists may prevent preterm labor by reducing cervical dysfunction.

This paper develops a human lymphoid follicle chip platform to model intramuscular mRNA vaccine responses, showing it can replicate immune responses to both naive and recall antigens.

This paper introduces Organ Chips with integrated sensors for continuous metabolic monitoring under controlled oxygen levels, demonstrating functionality in human Gut and Liver Chip cultures.

This study shows that alveolar macrophages worsen influenza-induced lung injury in a human lung alveolus chip, but blocking pyroptosis reduces inflammation and tissue damage.

The paper shows that cervical mucus from Organ Chips protects vaginal chips from inflammation and injury caused by bacterial vaginosis microbiomes, suggesting potential biomarkers and therapeutic targets.

This paper identifies vorinostat as a potential repurposed therapy for Rett syndrome by combining computational network analysis with CRISPR-edited Xenopus models, showing efficacy across multiple organ systems.

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.

The paper describes a Bone Marrow-on-a-Chip model that mimics bone marrow function and disease states, including drug and radiation responses and Shwachman-Diamond Syndrome abnormalities.

This study develops an Organ-on-a-Chip system to culture human intestinal epithelium with gut microbiota, showing increased microbial diversity and barrier function under hypoxia.