Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease
Alfie R. Wearn, Kate M. Onuska, Hayley R. C. Shanks…·R. Nathan Spreng
Author
Montreal Neurological Institute and HospitalORCID 0000-0001-9198-2780Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Alfie R. Wearn, Kate M. Onuska, Hayley R. C. Shanks…·R. Nathan Spreng
Maria Teodora Secara, Zara Khan, Ayesha G Rashidi…·Colin S. Hawco
This study examines BOLD signal variability in autism and schizophrenia, finding reduced variability in these groups compared to controls, linked to poorer cognitive and functional outcomes.
Joshua B. Tan, Isabella F Orlando, Jungwoo Kim…·James M. Shine
The paper uses fMRI and recurrent neural networks to show that compositional cognition involves specialized cortical regions for components and a distributed cortico-cerebellar network for recombination.
Joshua B. Tan, Isabella F Orlando, Christopher J. Whyte…·James M. Shine
The paper investigates the role of cerebellar and subcortical regions in working memory manipulation using fMRI during a mental rotation task, finding increased BOLD activity and delayed responses in these areas with larger rotation angles.
Eli J. Müller, Brandon Munn, Giulia Baracchini…·James M. Shine
This study shows the thalamus controls cortical dynamics across conscious states using fMRI, electrophysiology, and biophysical modeling.
Nagashree Thovinakere, Meishan Ai, Adrián Noriega de la Colina…·Maiya Rachel Geddes
The paper investigates brain connectivity patterns associated with long-term smoking behavior change in older adults at risk for Alzheimer's disease.
Giulia Baracchini, Yigu Zhou, Jason da Silva Castanheira…·R. Nathan Spreng
This study investigates the variability of fMRI BOLD signals in the human brain, showing it reflects multi-scale brain organization rather than noise.
Caitlin S. Walker, LINDA C. LI, Giulia Baracchini…·Maiya Rachel Geddes
The study examines how generativity affects purpose in life in at-risk older adults, finding social support as a mediator and prefrontal connectivity as a moderator.
Roni Setton, Laetitia Mwilambwe-Tshilobo, Manesh Girn…·R. Nathan Spreng
This study examines age-related changes in brain functional architecture using multi-scale fMRI analyses in younger and older adults, finding both global and network-specific dedifferentiation patterns.