Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease
Alfie R. Wearn, Kate M. Onuska, Hayley R. C. Shanks…·R. Nathan Spreng
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Douglas Mental Health University InstituteORCID 0000-0001-5824-3740Unclaimed ORCID profile · follow to get notified of new preprints
10 papers
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Alfie R. Wearn, Kate M. Onuska, Hayley R. C. Shanks…·R. Nathan Spreng
Larissa Fischer, Jenna N. Adams, Eóin N. Molloy…·Robert Jr Laforce
The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.
Kate M. Onuska, Hayley R.C. Shanks, Lauren A. Devito…·Taylor W. Schmitz
The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.
Larissa Fischer, Jenna N. Adams, Eóin N. Molloy…·Anne Maaß
The paper examines how aging, Alzheimer's pathology, and APOE4 genotype affect longitudinal functional connectivity and episodic memory in older adults.
Larissa Fischer, Eóin N. Molloy, Alexa Pichet Binette…·Anne Maaß
The paper examines how precuneus activity during memory retrieval relates to future amyloid burden and cognitive outcomes in APOE4 carriers and non-carriers.
Alexandre Poirier, Cynthia Picard, Anne Labonté…·Michel L. Tremblay
The paper identifies PTPRS as a neuroprotective marker in Alzheimer's disease, showing associations with reduced tau pathology and synaptic degeneration, particularly in males.
Nagashree Thovinakere, Meishan Ai, Adrián Noriega de la Colina…·Maiya Rachel Geddes
The paper investigates brain connectivity patterns associated with long-term smoking behavior change in older adults at risk for Alzheimer's disease.
Caitlin S. Walker, LINDA C. LI, Giulia Baracchini…·Maiya Rachel Geddes
The study examines how generativity affects purpose in life in at-risk older adults, finding social support as a mediator and prefrontal connectivity as a moderator.
Olivier Parent, Aurélie Bussy, Gabriel A. Devenyi…·Marianne Dufour
This study assesses white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease by analyzing signal measures from different MRI contrasts and their associations with clinical variables.
Jennifer Tremblay‐Mercier, Cécile Madjar, Samir Das…·John C.S. Breitner