R. Nathan Spreng

This study examines how control energy in brain networks changes over time in older adults at risk for Alzheimer's disease, finding specific patterns linked to cognitive performance and biomarkers.

This study introduces a neuroimaging framework to discover state-dependent signal flow hierarchy in the human cerebral cortex using integrated effective connectivity and signal flow mapping.

HippoGenes creates transcriptomic maps of the human hippocampus using spatial statistical models and the Allen Human Brain Atlas, enabling subregional gene expression analysis and disease-related molecular decoding.

This paper investigates thalamocortical dynamics during theory of mind tasks using fMRI and sEEG, finding that the thalamus coordinates default network activity through phase-amplitude coupling without local activation.

This study uses meta-analysis to show that mPFC/dACC processes task demand and reward separately, with caudal regions integrating them to reflect cost-benefit trade-offs in effort investment.

This study uses activity flow mapping to show reduced task activation prediction accuracy in TLE and FLE patients, linking intrinsic network dysconnectivity to memory impairments.

The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.

The paper examines how cognitive states like resting and movie watching affect large-scale brain functional connectivity using fMRI data from the HCP and PNI datasets.

The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.

The paper introduces the Network Correspondence Toolbox (NCT) to evaluate spatial correspondence between novel neuroimaging results and existing brain atlases, enabling standardized reporting and comparison across studies.

The paper examines sex-specific and APOE4-related associations between cardiometabolic risk factors and white matter microstructure in individuals with a family history of Alzheimer's disease.

The paper investigates fast neural coordination across brain regions during autobiographical memory processing using intracranial recordings in humans.

The paper identifies PTPRS as a neuroprotective marker in Alzheimer's disease, showing associations with reduced tau pathology and synaptic degeneration, particularly in males.

The paper investigates brain connectivity patterns associated with long-term smoking behavior change in older adults at risk for Alzheimer's disease.

This study uses MRI and deformation-based morphometry to show that nucleus basalis of Meynert degeneration occurs earlier than entorhinal cortex or hippocampus degeneration in Alzheimer's disease.

This study investigates the variability of fMRI BOLD signals in the human brain, showing it reflects multi-scale brain organization rather than noise.

The paper replicates an association between conscientiousness and efficiency of the salience/ventral attention network across three samples using individualized parcellation.

The paper evaluates the psychometric properties of the Autobiographical Interview in healthy adults, finding strong reliability and convergent validity but limited support for its two-factor structure.

The study examines how generativity affects purpose in life in at-risk older adults, finding social support as a mediator and prefrontal connectivity as a moderator.

This study identifies widespread brain-body co-fluctuations across multiple physiological systems and shows they are linked to autonomic nervous system activity.

Neurotransmitter receptor/transporter PET maps (19 targets, 1239 healthy participants) align with connectomes, explain MEG power, and track cognitive gradients and cortical thinning in 13 disorders.

The paper shows lifespan changes in global signal topography in the human brain, with distinct patterns in subcortical and cortical regions, suggesting a dual-layer model of the signal.

This study shows that structure-function coupling in the brain is dynamic and regionally heterogeneous, revealing organized patterns linked to cortical hierarchies and connection lengths.

This study shows that LSD and psilocybin reduce hierarchical cortical organization by flattening connectivity gradients, supporting a mechanistic model of the psychedelic state.

This study examines age-related changes in brain functional architecture using multi-scale fMRI analyses in younger and older adults, finding both global and network-specific dedifferentiation patterns.

The paper shows that lacking social support is linked to structural differences in how hippocampus and default network regions co-vary, with distinct patterns in left and right hemispheres.

The paper links subjective social isolation to specific subregional co-variation between the default network and hippocampus subfields using UK Biobank data.

The paper introduces a multilingual fMRI corpus using the audiobook The Little Prince to study cross-linguistic differences in language processing.

The paper develops individual-specific areal-level parcellations using a Bayesian model and shows they improve functional connectivity prediction of behavior compared to group-level parcellations.