Patrick T.F. Kennedy

This study shows that people with HBV/HIV co-infection maintain functional HBV-specific CD4+ T helper responses and coordinated CD4/CD8 antiviral immunity, suggesting preserved antiviral immunity.

This study expands adaptive NKG2C+ NK cells from HBV-infected donors, showing enhanced ADCC and anti-hepatoma activity.

This study shows PD-1 is essential for early HBV-specific CD8+ T cell expansion and survival during acute infection but does not suppress effector cytokine function, and its absence impairs proliferation and promotes exhaustion in chronic infection.

This study finds that auto-antibodies against interferons are common in chronic hepatitis B patients and linked to PegIFN treatment non-response.

This study introduces HBV-CRA, a rapid whole-blood assay that identifies immune profiles associated with HBsAg clearance and reveals heterogeneous T cell responses in chronic hepatitis B patients.