ImmunologyScience ImmunologyPeer-reviewed
Autoantigen TRIM21 (Ro52) assembles pro-inflammatory immune complexes following lytic cell death
Esther L. Jones Evans, Benjamin Demarco, Han Cai…·Lynn B. Dustin
The paper shows TRIM21 becomes an autoantigen by forming pro-inflammatory immune complexes after lytic cell death, which are taken up by macrophages and drive inflammation.
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