Author

Simei He

Yunnan Agricultural UniversityORCID 0000-0001-9239-7364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Organism:plant (other)· 1

Frequent Co-Authors

Geng CheniD· 2 shared GuangHui ZhangiD· 2 shared Guisheng XiangiD· 2 shared Yan ZhaoiD· 2 shared Bing HaoiD· 1 shared Changhao Fu· 1 shared Jinglei Xiong· 1 shared Lei Qiu· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Geng ChenORCID

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2 papers

Recent·Most cited

Genome evolution and glycosyltransferase diversification shape asperosaponin biosynthesis in Dipsacus asperoides

Run Yang, Changhao Fu, Xiu Zhao, Yan Zhao, Weiping Huang, Mingyu Li, Guisheng Xiang, Jinglei Xiong, Yina Wang, Geng Chen, Qize Liu, Shengchao Yang, GuangHui Zhang, Simei He, Yanli Liang

The paper reconstructs the asperosaponin biosynthesis pathway in Dipsacus asperoides by integrating genomics, transcriptomics, and biochemical analyses, revealing gene family diversification and glycosylation order.

bioRxiv · Nov 5, 2026 · PreprintGenomics

Pathway elucidation of pharmaceutical cucurbitacin IIa in Hemsleya chinensis and high-level production of precursor cucurbitadienol in engineered Saccharomyces cerevisiae and Nicotiana benthamiana

Geng Chen, Zhaokuan Guo, Yan Zhao, Yanyu Shu, Lei Qiu, Shao-feng Duan, Yuan Lin, Simei He, Xiaobo Li, Xiao‐Lin Feng, Guisheng Xiang, Yang Shi, Sheng-Chao Yang, Guanghui Zhang, Bing Hao

This study elucidates the biosynthetic pathway of cucurbitacin IIa in Hemsleya chinensis and demonstrates high-level production of its precursor in yeast and tobacco.

bioRxiv · Sep 28, 2022 · PreprintSynthetic Biology