Cancer BiologyPLoS Computational BiologyPeer-reviewed
Spatiotemporal dynamics of tumor-CAR T-cell interaction following local administration in solid cancers
Katherine L. Owens, Aminur Rahman, Ivana Božić
This study develops a spatiotemporal model to simulate CAR T-cell therapy in solid tumors, showing that local administration is most effective against slow-growing, highly diffusive tumors with low cell density.