Ivana Božić

This paper introduces a numerical integration scheme to compute survival probabilities in clonal expansion processes on arbitrary graphs, demonstrating its application to parameter inference in a graphical model.

The paper quantifies how early-stage cancer increases cell-free DNA levels from healthy tissue, not tumors, and explains this through a saturation model of clearance.

This study develops a spatiotemporal model to simulate CAR T-cell therapy in solid tumors, showing that local administration is most effective against slow-growing, highly diffusive tumors with low cell density.

The paper models mutation accumulation during cancer progression, analyzing premalignant population sizes and waiting times to malignancy in colorectal cancer and chronic myeloid leukemia.

PhylogicNDT statistically reconstructs cancer driver timing, subclonal phylogenies, and population dynamics from single- or multi-timepoint sequencing, revealing subtype-specific trajectories and therapy resistance evolution across 498 lung adenocarcinomas.