Jason G. Mezey

The paper identifies genetic variants that influence DNA methylation stability and imprint deregulation in naive pluripotent stem cells across different mouse strains.

The paper assesses genetic risks of inaccurate ICU drug dosing in Qataris by analyzing whole genome sequencing data and identifies population-specific pharmacogenomics variants.

This study benchmarks 26 variations of polygenic risk score models to assess how different assumptions affect disease prediction accuracy using UK Biobank data.

This paper introduces PheLEx, a Bayesian framework to detect and correct misclassified phenotypes in GWAS, improving recovery of disease loci and identifying new candidate loci in epilepsy and bipolar disorder.

This paper evaluates the clinical impact of polygenic risk scores across 23 diseases using UK Biobank data, showing improved prediction accuracy and actionable risk mitigation strategies.

The paper analyzes bulk RNA-seq data to identify factors influencing immune cell infiltration in human tissues, finding associations with age, sex, and genetic variants.

DRUID improves relative detection by inferring IBD sharing of ungenotyped ancestors, outperforming PADRE in identifying relatives and reducing generational gaps.

This study evaluates 12 relatedness inference methods using genome-wide data from 2,485 relatives, finding high accuracy for first and second degree relationships but significant drops for seventh degree relationships.