Author

Rachel A. Glenn

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 4 Genetics· 2

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Organism:mouse· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2

Frequent Co-Authors

Thomas VierbucheniD· 6 shared Effie ApostolouiD· 3 shared Hyunwoo ChoiD· 3 shared Daniel Medina-CanoiD· 2 shared Emily K. Corrigan· 2 shared Emily SwanzeyiD· 2 shared Matthias StadtfeldiD· 2 shared Richard P. KocheiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

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10 top collaborators · 32 mutual co-author links

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6 shared papersDevelopmental Biology

Thomas VierbuchenORCID

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6 papers

Recent·Most cited

NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions

Zhangli Ni, Xiaohui Ma, Stephanie Do, Lingling Cheng, Rachel A. Glenn, Thomas Vierbuchen, Alexandros Pertsinidis

This study shows NIPBL-mediated 3D genome folding is essential for enhancer-promoter communication and maintaining lineage fidelity during embryonic development.

bioRxiv · Dec 31, 2025 · PreprintGenetics

Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells

Chirag R. Parikh, Rachel A. Glenn, Yufang Shi, K. Chatterjee, Kritika Kasliwal, Emily Swanzey, S. Singer, S.C. Do, Yingqian Ada Zhan, Yasuhide Furuta, Mamta Tahiliani, Effie Apostolou, Alexandros Polyzos, Richard P. Koche, Jason G. Mezey, , Matthias Stadtfeld

The paper identifies genetic variants that influence DNA methylation stability and imprint deregulation in naive pluripotent stem cells across different mouse strains.

Stem Cell Reports · Mar 13, 2025Peer-reviewedDevelopmental Biology

A pluripotent stem cell platform for in vitro systems genetics studies of mouse development

Rachel A. Glenn, C. Stephanie, Karthik Guruvayurappan, Emily K. Corrigan, Laura Santini, Daniel Medina-Cano, Sarah Singer, Hyunwoo Cho, Jing Liu, Karl W. Broman, Anne Czechanski, Laura G. Reinholdt, Richard P. Koche, Yasuhide Furuta, Meik Kunz, Thomas Vierbuchen

This paper establishes a pluripotent stem cell platform using genetically diverse mouse lines to study the impact of natural genetic variation on development and gene regulation.

bioRxiv · Jun 6, 2024 · PreprintDevelopmental Biology

Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

Renhe Luo, Jielin Yan, Jin Woo Oh, Xi Wang, Dustin Shigaki, Wilfred Wong, Hyunwoo Cho, Dylan Murphy, Ronald R. Cutler, Bess P. Rosen, Julián Pulecio, Dapeng Yang, Rachel A. Glenn, Tingxu Chen, Qing V. Li, , M Beer

The paper uses a CRISPRi screen in hESC differentiation to identify enhancers with nonlinear regulatory activity, revealing a CTCF loop-constrained model for improved enhancer prediction.

Nature Genetics · Jul 24, 2023Peer-reviewedGenetics

Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids

Daniel Medina-Cano, Emily K. Corrigan, Rachel A. Glenn, Mohammed Tarek Islam, Yuan Lin, Juliet Kim, Hyunwoo Cho, Thomas Vierbuchen

The paper presents optimized protocols for generating definitive endoderm and forebrain-patterned neural organoids from mouse epiblast stem cells.

Development · Jul 28, 2022Peer-reviewedDevelopmental Biology

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus

Boaz E. Aronson, Laurianne Scourzic, Veevek Shah, Emily Swanzey, Andreas Kloetgen, Alexander Polyzos, Abhishek Sinha, Annabel Azziz, Inbal Caspi, Jiexi Li, Bobbie Pelham‐Webb, Rachel A. Glenn, Thomas Vierbuchen, Hynek Wichterle, Aristotelis Tsirigos, , Effie Apostolou

The paper identifies a bipartite imprinting control region at the Dlk1-Dio3 locus that maintains imprint stability through allele-specific regulation of DNA methylation and chromatin structure.

Developmental Cell · Oct 27, 2021Peer-reviewedDevelopmental Biology