Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development
Juanjuan Zhao, Susann Bruche, Konstantinos Lekkos, Carolyn A. Carr, Joaquim Miguel Vieira, John G. Parnavelas, William D. Andrews, Mathilda T.M. Mommersteeg
This study identifies the Slit2-Robo1 pathway as critical for cardiac sympathetic innervation during development, showing reduced innervation in Slit2-/- and Robo1-/- mice.
eLife · Dec 17, 2025Peer-reviewedDevelopmental Biology