Adult oligodendrogenesis gates arcuate neuronal glucose sensing through remodelling of the blood-hypothalamus barrier via ADAMTS4
Sophie A Buller, Emily O. Staricoff, Christine H. Riches, Anthony H. K. Tsang, Maša Josipović, Kentaro Ikemura, Gabriel Opoku, Ikumi Sato, Satoshi Hirohata, Saskia Stenzel, Stuart G. Nayar, Marta Ramos Vega, Jacob Hecksher‐Sørensen, Sebastian Timmler, Georgina K.C. Dowsett, , Clémence Blouet
This study shows that adult oligodendrogenesis in the median eminence regulates glucose homeostasis through ADAMTS4 expression, impacting the blood-hypothalamus barrier and neuronal glucose sensing in the arcuate nucleus.
bioRxiv · Sep 10, 2024 · PreprintNeuroscience