Georgina K.C. Dowsett

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

This study shows MRAP2 interacts with MC3R to enhance its signaling, affecting energy homeostasis and obesity risk.

NodoMap: a spatio-cellular map of the mouse nodose ganglia

The paper creates a spatio-cellular map of the mouse nodose ganglia using single nucleus RNA sequencing and spatial transcriptomics, revealing subtype-specific gene expression and spatial organization.

Enteropancreatic neurons drive the glucoregulatory response to ingested lipid

This study shows that enteropancreatic neurons expressing NTSR1 mediate olive oil's effect on glucose tolerance by stimulating insulin release.

Adult oligodendrogenesis gates arcuate neuronal glucose sensing through remodelling of the blood-hypothalamus barrier via ADAMTS4

This study shows that adult oligodendrogenesis in the median eminence regulates glucose homeostasis through ADAMTS4 expression, impacting the blood-hypothalamus barrier and neuronal glucose sensing in the arcuate nucleus.

A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding

The paper identifies GABAergic neurons in the nucleus of the solitary tract (NTS) as a new modulator of feeding behavior and body weight by suppressing orexigenic AgRP/NPY neurons through projections to the hypothalamic arcuate nucleus.

Human HYPOMAP: A comprehensive spatio-cellular map of the human hypothalamus

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease

The paper identifies protein-truncating variants in BSN associated with severe adult-onset obesity, type 2 diabetes, and fatty liver disease, with no effect on childhood adiposity.

Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

This study identifies brainstem GLP-1 neurons as essential for lorcaserin's effect on reducing food intake in mice and suggests combination therapy with GLP-1R agonists may enhance efficacy.

The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes

This study shows that NrCAM regulates adult hypothalamic tanycytes, affecting their numbers and marker expression, but with only subtle metabolic consequences.

A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.