Sophie A Buller

This study shows that adult oligodendrogenesis in the median eminence regulates glucose homeostasis through ADAMTS4 expression, impacting the blood-hypothalamus barrier and neuronal glucose sensing in the arcuate nucleus.

This study shows that myelin in the adult mouse median eminence continuously turns over, regulated by nutritional status and microglia.

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.