Author

Juliane Lüscher‐Firzlaff

RWTH Aachen UniversityORCID 0000-0001-9265-8536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Alexander T. StenzeliD· 2 shared Bernhard LüscheriD· 2 shared Mirna BarsoumiD· 2 shared Philip BussmanniD· 2 shared Roksaneh Sayadi-BoroujeniiD· 2 shared Anna-Maria VllahoiD· 1 shared Christoph KuppeiD· 1 shared Janina MülleriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Alexander T. StenzelORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 4, 2026

Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells

Janina Müller, Mirna Barsoum, Philip Bussmann…·Bernhard Lüscher

The paper shows that reversing PROTAC-induced ASH2L degradation restores H3K4me3, gene expression, and proliferation in senescent cells.

DOI 10.64898/2026.05.02.722411

𝕏 PostBluesky

Molecular BiologyScientific ReportsPeer-reviewedDec 19, 2023

Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L

Mirna Barsoum, Roksaneh Sayadi-Boroujeni, Alexander T. Stenzel…·Bernhard Lüscher

This study shows that ASH2L degradation via PROTAC leads to sequential changes in histone marks, chromatin accessibility, and gene expression, revealing delayed downstream effects on transcription.

5 citations

𝕏 PostBluesky