Author

Alexander T. Stenzel

RWTH Aachen UniversityORCID 0000-0002-6633-480XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Bernhard LüscheriD· 2 shared Juliane Lüscher‐FirzlaffiD· 2 shared Mirna BarsoumiD· 2 shared Philip BussmanniD· 2 shared Roksaneh Sayadi-BoroujeniiD· 2 shared Anna-Maria VllahoiD· 1 shared Christoph KuppeiD· 1 shared Janina MülleriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Bernhard LüscherORCID

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2 papers

Recent·Most cited

Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells

Janina Müller, Mirna Barsoum, Philip Bussmann, Mohamed H. Elsafi Mabrouk, Roksaneh Sayadi-Boroujeni, Anna-Maria Vllaho, Alexander T. Stenzel, Lukas Vogt, Paul Kießling, Christoph Kuppe, Juliane Lüscher‐Firzlaff, Bernhard Lüscher

The paper shows that reversing PROTAC-induced ASH2L degradation restores H3K4me3, gene expression, and proliferation in senescent cells.

bioRxiv · May 4, 2026 · PreprintCell Biology

Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L

Mirna Barsoum, Roksaneh Sayadi-Boroujeni, Alexander T. Stenzel, Philip Bussmann, Juliane Lüscher‐Firzlaff, Bernhard Lüscher

This study shows that ASH2L degradation via PROTAC leads to sequential changes in histone marks, chromatin accessibility, and gene expression, revealing delayed downstream effects on transcription.

Scientific Reports · Dec 19, 2023Peer-reviewedMolecular Biology