Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest
Sina Danesh, Fazal Wahab Khan, Trevor C. Chopko, Aurora Lee, Ran Huo, Shuyang Lu, Vincy Tam, J. Pedro Safi, Wenbin Gao, Austin Todd, Francis D. Pagani, Joseph John Maleszewski, Hartzell Vernon Schaff, Paul A. Friedman, Hakan Oral, , Paul C. Y. Tang
This study shows preoperative MRA use reduces new-onset POAF and long-standing AF development, with canrenone suppressing MR target genes linked to chronic AF in atrial cardiomyocytes during cold preservation.
Journal of the American Heart Association · Oct 9, 2025Peer-reviewedMolecular Biology