ImmunologybioRxivPreprint
Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43
Beibei Zhao, Sarah Louadi, Juliane A. Coutts…·Neil R. Cashman
This paper generates monoclonal antibodies and intrabodies that selectively target misfolded TDP-43 aggregates in disease, showing they inhibit transmission and promote degradation in cell models.
DOI 10.1101/2025.06.10.658846