Author

Johanne M Kaplan

Amorfix (Canada)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Ebrima GibbsiD· 2 shared Ian R. MackenzieiD· 2 shared Juliane A. Coutts· 2 shared Neil R. CashmaniD· 2 shared Anke A. Djikstra· 1 shared Beibei ZhaoiD· 1 shared Beibei ZhaoiD· 1 shared Byron W. CaugheyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Ebrima GibbsORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Relationship between therapeutic activity and preferential targeting of toxic soluble aggregates by amyloid-beta-directed antibodies

Johanne M Kaplan, Ebrima Gibbs, Juliane A. Coutts, Beibei Zhao, Ian R. Mackenzie, Steven Samuel Plotkin, Neil R. Cashman

The paper examines how the binding selectivity of amyloid-beta antibodies to toxic oligomers correlates with therapeutic efficacy and reduced risk of adverse effects in Alzheimer's disease.

Alzheimer s & Dementia Translational Research & Clinical Interventions · Oct 1, 2025Peer-reviewedNeuroscience

Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43

Beibei Zhao, Sarah Louadi, Juliane A. Coutts, Ebrima Gibbs, Megan Y. Huang, Ryan J. Marina, Stefan Aigner, Parvez Alam, Mari L. DeMarco, Ian R. Mackenzie, Anke A. Djikstra, Byron W. Caughey, Gene Wei-Ming Yeo, Johanne M Kaplan, Neil R. Cashman

This paper generates monoclonal antibodies and intrabodies that selectively target misfolded TDP-43 aggregates in disease, showing they inhibit transmission and promote degradation in cell models.

bioRxiv · Jun 10, 2025 · PreprintImmunology