Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43
Beibei Zhao, Sarah Louadi, Juliane A. Coutts, Ebrima Gibbs, Megan Y. Huang, Ryan J. Marina, Stefan Aigner, Parvez Alam, Mari L. DeMarco, Ian R. Mackenzie, Anke A. Djikstra, Byron W. Caughey, Gene Wei-Ming Yeo, Johanne M Kaplan, Neil R. Cashman
This paper generates monoclonal antibodies and intrabodies that selectively target misfolded TDP-43 aggregates in disease, showing they inhibit transmission and promote degradation in cell models.
bioRxiv · Jun 10, 2025 · PreprintImmunology