Cell BiologybioRxivPreprint
AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis
Hee Yeon Kim, Daniel Youngjae Park, Eun Hye Cho…·Yong Tae Kwon
This study identifies the N-degron pathway's role in lysosomal degradation of TTRV30M aggregates and demonstrates the therapeutic potential of AUTOTAC-based degraders for hATTR.
DOI 10.64898/2026.02.23.707350